Presentazione:

BIOLOGIST
SC Neurologia 3 - Neuroalgologia
(italian version)

 

I am a cell biologist devoted to the study of the functional organization of the neuronal cytoskeleton and microtubule-dependent processes, both in physiological and pathological conditions. I work at various levels, from the studies of the interaction of pure proteins to the analyses of animal models and human samples. Although during my career I used many different techniques, that span from biochemical studies to behavioural tests and ex vivo analyses, I really believe in the motto “seeing is believing”, and i dedicated myself to the use microscopies and live cell imaging. Indeed, due to my great experience in the field, I’m partecipating to the creation of an Imaging Facility at the Neurological Institute Carlo Besta.   

 

Research activity

For a decade I worked in the field of Parkinson’s disease, and the combination of multiple approaches allowed me to identify microtubule dysfunction as one of the degenerative mechanism underlying pathology progression and concrete hints about new biological roles of Parkinson’s disease-related proteins (Parkin and α-Synuclein). Now, I moved to the study of peripheral nervous system and I’m focusing on the identification of the cellular culprits responsible for the degeneration of sensory neurons and how the modulation of microtubule cytoskeleton could prompt fibres’ regeneration. 

 

Topics of interest

• Microscopy
• Neurodegeneration
• Cytoskeleton

 

 

Contacts

+39 02.2394.2727

email: daniele.cartelli@istituto-besta.it