Presentazione:

BIOLOGO
SC  Neurologia 7 - Epilettologia Clinica e Sperimentale
(italian version)

 

I work in preclinical research, in particular on drug-resistant epileptogenic mutations and neuronal excitability linked to epileptic diseases. I graduated in Biology in 2002 and my career started immediately in this foundation as an electrophysiologist with the study, in vitro, of drug-resistant epilepsies and migraines, obtaining the PhD in 2008.

 

Research activity

I study, with the patch-clamp technique through the use of genetically modified animal models and in vitro specimens, the modifications induced by the mutations from an electrophysiological point of view, which allows to record the currents and action potentials generated by the ion channels.

The results obtained make it possible to shed light, at a molecular and biophysical level, on the defects in the conduction of nerve impulses in the preparations under study.

The use of animal models and the study of their phenotype makes it possible to test new drugs and new therapeutic approaches in order to correct and / or restore the abnormalities caused by the mutations themselves

 

Topics of interest

• Epilepsy
• Ionic channels
• Neuronal excitability

 

 

Contacts

+39 02.2394.4523

email: paolo.scalmani@istituto-besta.it